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Article

Tissue-specific and tissue-agnostic effects of genome sequence variation modulating blood pressure.

Cell reports - 28 Nov 2023

Lee Dongwon, Han Seong Kyu, Yaacov Or, Berk-Rauch Hanna, Mathiyalagan Prabhu, Ganesh Santhi K, Chakravarti Aravinda

Abstract excerpt

Genome-wide association studies (GWASs) have identified numerous variants associated with polygenic traits and diseases. However, with few exceptions, a mechanistic understanding of which variants affect which genes in which tissues to modulate trait variation is lacking. Here, we present genomic analyses to explain trait heritability of blood pressure (BP) through the genetics of transcriptional regulation using...

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Identifiers

PMID: 37910504
DOI: 10.1016/j.celrep.2023.113351
PMCID: PMC10726310

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