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Article

Prediction and Subtyping of Hypertension from Pan-Tissue Transcriptomic and Genetic Analyses.

Genetics - 1 Nov 2017

Basu Mahashweta, Sharmin Mahfuza, Das Avinash, Nair Nishanth Ulhas, Wang Kun, Lee Joo Sang, Chang Yen-Pei Christy, Ruppin Eytan, Hannenhalli Sridhar

Abstract excerpt

Hypertension (HT) is a complex systemic disease involving transcriptional changes in multiple organs. Here we systematically investigate the pan-tissue transcriptional and genetic landscape of HT spanning dozens of tissues in hundreds of individuals. We find that in several tissues, previously identified HT-linked genes are dysregulated and the gene expression profile is predictive of HT. Importantly, many...

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Identifiers

PMID: 28899996
DOI: 10.1534/genetics.117.300280
PMCID: PMC5676229

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