Article

Vascular K <sub>ATP</sub> channel structural dynamics reveal regulatory mechanism by Mg-nucleotides

2021-05-16

Abstract excerpt

<h4>ABSTRACT</h4> Vascular tone is dependent on smooth muscle K ATP channels comprising pore-forming Kir6.1 and regulatory SUR2B subunits, in which mutations cause Cantú syndrome. Unique among K ATP isoforms, they lack spontaneous activity and require Mg-nucleotides for activation. Structural mechanisms underlying these properties are unknown. Here, we determined the first cryoEM structures of vascular K ATP c...

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Literature Corpus work: f58a5876-eec2-5609-93eb-b7f05c7eedb4
DOI: 10.1101/2021.05.15.444267

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