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Article

New insights into KATP channel gene mutations and neonatal diabetes mellitus.

Nature reviews. Endocrinology - 1 Jul 2020

Pipatpolkai Tanadet, Usher Samuel, Stansfeld Phillip J, Ashcroft Frances M

Abstract excerpt

The ATP-sensitive potassium channel (KATP channel) couples blood levels of glucose to insulin secretion from pancreatic β-cells. KATP channel closure triggers a cascade of events that results in insulin release. Metabolically generated changes in the intracellular concentrations of adenosine nucleotides are integral to this regulation, with ATP and ADP closing the channel and MgATP and MgADP increasing channel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32376986
DOI: 10.1038/s41574-020-0351-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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