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Article

Molecular structure of an open human KATP channel.

Proceedings of the National Academy of Sciences of the United States of America - 30 Nov 2021

Zhao Chen, MacKinnon Roderick

Abstract excerpt

KATP channels are metabolic sensors that translate intracellular ATP/ADP balance into membrane excitability. The molecular composition of KATP includes an inward-rectifier potassium channel (Kir) and an ABC transporter-like sulfonylurea receptor (SUR). Although structures of KATP have been determined in many conformations, in all cases, the pore in Kir is closed. Here, we describe human pancreatic KATP (hKATP)...

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Identifiers

PMID: 34815345
DOI: 10.1073/pnas.2112267118
PMCID: PMC8640745

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