Article
Molecular biology of K(ATP) channels and implications for health and disease.
IUBMB life - 1 Oct 2009
Akrouh Alejandro, Halcomb S Eliza, Nichols Colin G, Sala-Rabanal Monica
Abstract excerpt
The ATP-sensitive potassium (K(ATP)) channel is expressed in most excitable tissues and plays a critical role in numerous physiological processes by coupling intracellular energetics to electrical activity. The channel is comprised of four Kir6.x subunits associated with four regulatory sulfonylurea receptors (SUR). Intracellular ATP acts on Kir6.x to inhibit channel activity, while MgADP stimulates channel...
Topics
- ATP-Binding Cassette Transporters
- Adenosine Diphosphate
- Adenosine Triphosphate
- Animals
- Diabetes Mellitus
- Disease
- Health
- Humans
- Hyperinsulinism
- KATP Channels
- Molecular Biology
- Mutation
- Potassium Channels, Inwardly Rectifying
- Receptors, Drug
- Sulfonylurea Receptors