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Article

ATP-sensitive K+ channel channel/enzyme multimer: metabolic gating in the heart.

Journal of molecular and cellular cardiology - 1 Jun 2005

Alekseev Alexey E, Hodgson Denice M, Karger Amy B, Park Sungjo, Zingman Leonid V, Terzic Andre

Abstract excerpt

Cardiac ATP-sensitive K(+) (K(ATP)) channels, gated by cellular metabolism, are formed by association of the inwardly rectifying potassium channel Kir6.2, the potassium conducting subunit, and SUR2A, the ATP-binding cassette protein that serves as the regulatory subunit. Kir6.2 is the principal site of ATP-induced channel inhibition, while SUR2A regulates K(+) flux through adenine nucleotide binding and...

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Identifiers

PMID: 15910874
DOI: 10.1016/j.yjmcc.2005.02.022
PMCID: PMC2736952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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