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A mitochondrial topoisomerase IA essential for late theta structure resolution in African trypanosomes

20 Dec 2007

Abstract excerpt

Trypanosomes and Leishmania, protozoans that cause major human diseases, have a topologically intricate mitochondrial DNA (kinetoplast or kDNA) in the form of a network of thousands of interlocked circles. This unusual system provides a useful reporter for studying topoisomerase functions in vivo. We now find that these organisms have three type IA topoisomerases, one of which is phylogenetically distinctive and...

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PMID: 18179422
DOI: 10.1111/j.1365-2958.2007.06087.x

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