Article

Genomic Flexibility Through Extrachromosomal Amplifications: A <i>Leishmania</i> Survival Strategy

2025-12-14

Abstract excerpt

Leishmania parasites modulate gene copy number through extrachromosomal DNA (ecDNA) amplification, enabling adaptation to environmental stress. Under drug pressure, both linear and circular ecDNA amplifications (amplicons) carrying resistance genes emerge. However, how these ecDNA structures form, diversify, and coexist remains poorly understood. Here, using experimental evolution and Oxford Nanopore long-read seq...

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Literature Corpus work: 96b30680-63bd-5d96-b7b4-3620f0293f44
DOI: 10.64898/2025.12.13.692850

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