Article

Cyclic nucleotide-induced superhelical structure activates a bacterial TIR immune effector

2022-05-04

Abstract excerpt

<h4>ABSTRACT</h4> Cyclic nucleotide signalling is a key component of anti-viral defence in all domains of life, from bacteria to humans. Viral detection activates a nucleotide cyclase to generate a second messenger, resulting in activation of effector proteins. This is exemplified by the metazoan cGAS-STING innate immunity pathway 1 , which originated in bacteria 2 . These defence systems require a sensor domai...

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Literature Corpus work: f550f0d1-df78-5fa5-80f0-06f5e4ea5dcc
DOI: 10.1101/2022.05.04.490601

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