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cGAS-STING: insight on the evolution of a primordial antiviral signaling cassette

8 Jun 2021

Abstract excerpt

Stimulator of interferon genes (STING) functions in the cytosolic DNA-sensing pathway of innate immunity in mammals. It is activated upon binding the cyclic dinucleotide 2'3'-cGAMP, a second messenger produced by the enzyme cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS), which acts as the receptor for DNA in this pathway, and triggers the expression of interferons and other viral...

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PMID: 34195693
DOI: 10.12703/r/10-54

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