Article

A miniature CRISPR-Cas10 enzyme confers immunity by an inverse signaling pathway

2025-03-30

Abstract excerpt

Microbial and viral co-evolution has created immunity mechanisms involving oligonucleotide signaling that share mechanistic features with human anti-viral systems 1 . In these pathways, including CBASS and type III CRISPR systems in bacteria and cGAS-STING in humans, oligonucleotide synthesis occurs upon detection of virus or foreign genetic material in the cell, triggering the antiviral response 2–4 . In a surp...

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Literature Corpus work: 34e5953f-fbb6-5009-8782-2f6ed63ac9a8
DOI: 10.1101/2025.03.28.646030

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