Article

Cyclic oligoadenylate signalling mediates <i>Mycobacterium tuberculosis</i> CRISPR defence

2019-06-12

Abstract excerpt

<h4>ABSTRACT</h4> The CRISPR system provides adaptive immunity against mobile genetic elements (MGE) in prokaryotes. In type III CRISPR systems, an effector complex programmed by CRISPR RNA detects invading RNA, triggering a multi-layered defence that includes target RNA cleavage, licencing of an HD DNA nuclease domain and synthesis of cyclic oligoadenylate (cOA) molecules. cOA activates the Csx1/Csm6 family of e...

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Literature Corpus work: 40a6cdf6-0e8e-524f-958f-3a4bea404c0c
DOI: 10.1101/667758

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