Article
STING polymer structure reveals mechanisms for activation, hyperactivation, and inhibition
2019-02-15
Abstract excerpt
How the central innate immune protein, STING, is activated by its ligands remains unknown. Here, using structural biology and biochemistry, we report that the metazoan second messenger 2’3’-cGAMP induces closing of the human STING homodimer and release of the STING C-terminal tail, which exposes a polymerization interface on the STING dimer and leads to the formation of disulfide-linked polymers via cysteine resid...
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Identifiers and source
- Literature Corpus work
- 11f7925b-755c-5c58-b705-32f2e2eeba5e
- DOI
- 10.1101/552166