Article

Ribosomal RNA Synthesis is a Lethal Vulnerability During Reductive Stress In <i>C</i> . <i>elegans</i>

2025-11-27

Abstract excerpt

Reductive stress has remained underappreciated as a significant disrupter of redox homeostasis. Recent studies have begun to link the accumulation of NADH and NADPH to the development and progression of metabolic diseases such as cancer, cardiac disease, and diabetes. Further research is needed to understand how cellular responses to reductive stress are governed. In this study we use the nematode Caenorhabditis...

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Literature Corpus work: f52e5857-e74c-5d05-b362-f2de5ac28426
DOI: 10.1101/2025.11.24.690266

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