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Maintenance of Complex I and respiratory super-complexes by NDUF-11 is essential for respiratory function, mitochondrial structure and health in <i>C. elegans</i>

2021-01-06

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial super-complexes form around a conserved core of monomeric complex I and dimeric complex III; wherein subunit NDUFA11, of the former, is conspicuously situated at the interface. We identified B0491 . 5 ( NDUF-11 ) as the C. elegans homologue, of which animals homozygous for a CRISPR-Cas9 generated knockout allele arrested at the L2 development stage. Reducing expression by RNAi...

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Literature Corpus work
d29f93ff-29b6-5ad4-aa3f-b54eae0b254c
DOI
10.1101/2021.01.06.425530
Open publication

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