HIRA loss transforms FH-deficient cells

Abstract excerpt

<h4>ABSTRACT</h4> Fumarate Hydratase (FH) is a mitochondrial enzyme that catalyses the reversible hydration of fumarate to malate in the TCA cycle. Germline mutations of FH lead to HLRCC, a cancer syndrome characterised by a highly aggressive form of renal cancer( 1 ). Although HLRCC tumours metastasise rapidly, FH-deficient mice develop premalignant cysts in the kidneys, rather than carcinomas ( 2 ). How Fh1...

Topics

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• Disease Management
• Enzyme function and inhibition
• Fumarate Hydratase
• Mutation
• Neoplasms
• Pancreatic and Hepatic Oncology Research
• Renal and related cancers
• Renal cell carcinoma treatment

Identifiers and source

Literature Corpus work

0199c44f-2e6f-5803-850d-655961f8dd57

DOI

10.1101/2022.06.04.492123