Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis.

doi:10.1371/journal.pmed.1001326

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Article

Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis.

PLoS medicine - 1 Jan 2012

Tansey Katherine E, Guipponi Michel, Perroud Nader, Bondolfi Guido, Domenici Enrico, Evans David, Hall Stephanie K, Hauser Joanna, Henigsberg Neven, Hu Xiaolan, Jerman Borut, Maier Wolfgang, Mors Ole, O'Donovan Michael, Peters Tim J, Placentino Anna, Rietschel Marcella, Souery Daniel, Aitchison Katherine J, Craig Ian, Farmer Anne, Wendland Jens R, Malafosse Alain, Holmans Peter, Lewis Glyn, Lewis Cathryn M, Stensbøl Tine Bryan, Kapur Shitij, McGuffin Peter, Uher Rudolf

Abstract excerpt

BACKGROUND: It has been suggested that outcomes of antidepressant treatment for major depressive disorder could be significantly improved if treatment choice is informed by genetic data. This study aims to test the hypothesis that common genetic variants can predict response to antidepressants in a clinically meaningful way. METHODS AND FINDINGS: The NEWMEDS consortium, an academia-industry partnership, assembled...

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Identifiers

PMID: 23091423
DOI: 10.1371/journal.pmed.1001326
PMCID: PMC3472989

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Source receipt: pubmed, retrieved 7 Sept 2026.

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