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Article

Higher polygenic risk scores for schizophrenia may be suggestive of treatment non-response in major depressive disorder.

Progress in neuro-psychopharmacology & biological psychiatry - 8 Jun 2021

Fanelli Giuseppe, Benedetti Francesco, Kasper Siegfried, Zohar Joseph, Souery Daniel, Montgomery Stuart, Albani Diego, Forloni Gianluigi, Ferentinos Panagiotis, Rujescu Dan, Mendlewicz Julien, Serretti Alessandro, Fabbri Chiara

Abstract excerpt

Up to 60% of patients with major depressive disorder (MDD) do not respond to the first treatment with antidepressants. Response to antidepressants is a polygenic trait, although its underpinning genetics has not been fully clarified. This study aimed to investigate if polygenic risk scores (PRSs) for major psychiatric disorders and trait neuroticism (NEU) were associated with non-response or resistance to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33181205
DOI: 10.1016/j.pnpbp.2020.110170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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