Article

Higher polygenic risk scores for schizophrenia may be suggestive of treatment non-response in major depressive disorder

2020-01-18

Abstract excerpt

<h4>Background</h4> Up to 60% of patients with major depressive disorder (MDD) do not respond to the first treatment with antidepressants. Response to antidepressants is a polygenic trait, although its underpinning genetics has not been fully clarified. This study aimed to investigate if Polygenic Risk Scores (PRSs) for major psychiatric disorders and neuroticism were associated with non-response or resistance to...

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Literature Corpus work: a114145f-1ded-5e3b-b1bb-f8d4a875f7d5
DOI: 10.1101/2020.01.15.20017699

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