Article

A polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genotyping

2019-09-20

Abstract excerpt

Treatment-resistant depression (TRD) occurs in ∼30% of patients with major depressive disorder (MDD) but the genetics of TRD was previously poorly investigated. Whole exome sequencing and genome-wide genotyping were performed in 1320 MDD patients. Response to the first pharmacological treatment was compared to non-response to one treatment and non-response to two or more treatments (TRD). Differences in the risk o...

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Literature Corpus work: 038aa289-1357-5ece-88c6-5ee07a94f28e
DOI: 10.1101/19007161

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