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Histone Deacetylase Inhibitors Improve Memory Function and Decrease Neuropathology in APP/PS1 Mice

2026-08-26

Abstract excerpt

<title>Abstract</title> <p>Although histone deacetylase (HDAC) inhibitors have shown therapeutic potential in aging and Alzheimer's disease (AD), direct comparisons of nonselective and selective HDAC inhibitors across aging and AD models are lacking. We compared the effects of the broad-spectrum HDAC inhibitor valproic acid (VPA) and the selective class I HDAC inhibitors entinostat (MS-275) and tacedinaline (CI-9...

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Literature Corpus work: f51bcb75-cf3e-55c4-8e73-b5dfe64667c2
DOI: 10.21203/rs.3.rs-10816126/v1

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