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Article

Neuronal HDAC9: A key regulator of cognitive and synaptic aging, rescuing Alzheimer's disease-related phenotypes.

Molecular psychiatry - 1 Aug 2026

Lei Yun, Chen Yuting, Guo Ming, Patel Florikaben, Bai Yu, Goo Brandee, Du Quansheng, Weintraub Neal L, Lu Xin-Yun

Abstract excerpt

Epigenetic regulation is a key determinant of the aging process, and its dysregulation contributes to cognitive aging and increased vulnerability to Alzheimer's disease (AD). As major regulators of epigenetic processes, histone deacetylases (HDACs) have emerged as potential therapeutic targets for cognitive enhancement in neurodegenerative diseases. However, the distinct roles of individual HDAC isoforms remain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41935184
DOI: 10.1038/s41380-026-03556-w
PMCID: PMC13364699

Genes

HDAC9
CA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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