Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Restoring the epigenome in Alzheimer's disease: advancing HDAC inhibitors as therapeutic agents

1 Jun 2024

Abstract excerpt

Current treatment options for Alzheimer's disease (AD) focus on symptom relief rather than halting disease progression. In this context, targeting histone deacetylation emerges as a promising therapeutic alternative. Dysregulation of histone deacetylase (HDAC) activity is present in AD, contributing to cognitive decline. Pharmacological HDAC inhibition has shown benefits in preclinical models, namely reduced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholinesterase and Neurodegenerative Diseases
Share to Histone Deacetylase Inhibitors Research
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38830501
DOI: 10.1016/j.drudis.2024.104052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Restoring the epigenome in Alzheimer's disease: advancing HDAC inhibitors as therapeutic agentsPMID 38830501Read ↗

Histone Deacetylase Inhibition in Alzheimer’s Disease: Molecular Mechanisms, Therapeutic Potential, and Future PerspectivesSemantic proximity Read ↗

Epigenetics in Alzheimer’s DiseaseSemantic proximity Read ↗

Epigenetic Changes in Alzheimer’s Disease: DNA Methylation and Histone ModificationSemantic proximity Read ↗

Histone Deacetylase 2 in Alzheimer’s Disease: A Comprehensive Molecular Blueprint for Therapeutic TargetingSemantic proximity Read ↗

Epigenetic Mechanisms in Alzheimer's DiseaseSemantic proximity Read ↗

Histone Modifications in Alzheimer’s DiseaseSemantic proximity Read ↗

HDAC3 as an Emerging Therapeutic Target for Alzheimer's Disease and other Neurological DisordersSemantic proximity Read ↗

Targeting HDACs: A Promising Therapy for Alzheimer's DiseaseSemantic proximity Read ↗

Targeting histone-modifications in Alzheimer's disease. What is the evidence that this is a promising therapeutic avenue?Semantic proximity Read ↗

Epigenetic regulation in Alzheimer’s disease: is it a potential therapeutic target?Semantic proximity Read ↗

Epigenetic modification is linked to Alzheimer's disease: is it a maker or a marker?Semantic proximity Read ↗

Epigenetic mechanisms in Alzheimer's disease: implications for pathogenesis and therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.