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Article

Targeting HDACs: A Promising Therapy for Alzheimer's Disease

1 Jan 2011

Abstract excerpt

Epigenetic modifications like DNA methylation and histone acetylation play an important role in a wide range of brain disorders. Histone deacetylases (HDACs) regulate the homeostasis of histone acetylation. Histone deacetylase inhibitors, which initially were used as anticancer drugs, are recently suggested to act as neuroprotectors by enhancing synaptic plasticity and learning and memory in a wide range of...

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PMID: 21941604
DOI: 10.1155/2011/143269

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