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Loss of HDAC5 Impairs Memory Function: Implications for Alzheimer's Disease

3 Dec 2012

Abstract excerpt

Epigenetic mechanisms such as histone-acetylation have been implicated with learning and memory and are believed to contribute to the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). Histone-deacetylase (HDAC) inhibitors were shown to exhibit neuroprotective and neurodegenerative properties in AD animal models, and targeting HDACs appears to be a promising therapeutic strategy for...

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PMID: 22914591
DOI: 10.3233/jad-2012-121009

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