Article

Histone deacetylase inhibitors VPA and WT161 ameliorate the pathological features and cognitive impairments of the Alzheimer's disease mouse model by regulating the expression of App secretases

2023-07-13

Abstract excerpt

<h4>Background: </h4> Alzheimer's disease (AD) is a degenerative neurological disorder. Recent studies have indicated that histone deacetylases (HDACs) are among the most prominent epigenetic therapy targets and that HDAC inhibitors have therapeutic effects on AD. Here, we identified sodium valproate (VPA), a pan-HDAC inhibitor, and WT161, a novel HDAC6 selective inhibitor, as potential therapeutic agents for AD....

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Literature Corpus work: d242d796-bebf-5311-9d09-ef34b5a2559b
DOI: 10.21203/rs.3.rs-3150862/v1

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