Article
Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Sept 2015
Rumbaugh Gavin, Daws Stephanie E, Ozkan Emin D, Rojas Camilo S, Hubbs Christopher R, Aceti Massimiliano, Kilgore Mark, Kudugunti Shashi, Puthanveettil Sathyanarayanan V, Sweatt J David, Rusche James, Miller Courtney A
Abstract excerpt
Histone deacetylases (HDACs) are promising therapeutic targets for neurological and psychiatric disorders that impact cognitive ability, but the relationship between various HDAC isoforms and cognitive improvement is poorly understood, particularly in mouse models of memory impairment. A goal shared by many is to develop HDAC inhibitors with increased isoform selectivity in order to reduce unwanted side effects,...
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