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Article

HDAC inhibitor–dependent transcriptome and memory reinstatement in cognitive decline models

16 Aug 2015

Abstract excerpt

Aging and increased amyloid burden are major risk factors for cognitive diseases such as Alzheimer's disease (AD). Effective therapies for these diseases are lacking. Here, we evaluated mouse models of age-associated memory impairment and amyloid deposition to study transcriptome and cell type-specific epigenome plasticity in the brain and peripheral organs. We determined that aging and amyloid pathology are...

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PMID: 26280576
DOI: 10.1172/jci79942

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