Article

Intranasal Anti-CD3 Antibody Treatment Attenuates Post–COVID Neuroinflammation and Enhances Hippocampal Neurogenesis and Cognitive Function in Mice

2026-04-08

Abstract excerpt

Cognitive impairment is a disabling feature of Long COVID, with data supporting neuroinflammation and maladaptive glial responses as primary drivers. Nasal administration of an anti-CD3 monoclonal antibody (aCD3 mAb) has shown therapeutic benefits in autoimmune and CNS disease models. Using a respiratory-restricted mild SARS-CoV-2 mouse model of Long COVID, we show that nasal anti-CD3 mAb, administered shortly aft...

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Literature Corpus work: f517943b-383f-583c-a8e6-b8503dc2052f
DOI: 10.64898/2026.04.07.716934

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