Back to search

Article

Ex vivo Expanded Human Regulatory T Cells Modify Neuroinflammation in a Preclinical Model of Alzheimer’s disease

2022-06-07

Abstract excerpt

<title>Abstract</title> <p>Background: Regulatory T cells (Tregs) play a neuroprotective role by suppressing microglia and macrophage-mediated inflammation and modulating adaptive immune reactions. We previously documented that Treg immunomodulatory mechanisms are compromised in Alzheimer’s disease (AD). <italic>Ex vivo</italic> expansion of Tregs restores and amplifies their immunosuppressive functions <italic>...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
171e15cd-3a3e-5ba0-9a02-1caafaa57d09
DOI
10.21203/rs.3.rs-1639205/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Ex vivo Expanded Human Regulatory T Cells Modify Neuroinflammation in a Preclinical Model of Alzheimer’s diseaseDOI 10.21203/rs.3.rs-1639205/v1
A preclinical and phase I clinical study of ex vivo-expanded amyloid beta-specific human regulatory T cells in Alzheimer’s diseaseSemantic proximity
5xFAD-NSG mice: a preclinical Alzheimer model for human cell therapy studiesSemantic proximity
A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseasesSemantic proximity
An integrated human forebrain organoid reveals microglia-mediated CD8⁺ T cell recruitment and neuroimmune dysfunction in Alzheimer’s disease pathologySemantic proximity
The AppNL-G-F mouse model of Alzheimer’s disease is refractory to regulatory T cell treatmentSemantic proximity
Single-cell multiomic analysis reveals the involvement of Type I interferon-responsive CD8+ T cells in amyloid beta-associated memory lossSemantic proximity
The <i>App</i> <sup> <i>NL-G-F</i> </sup> mouse model of Alzheimer’s disease is refractory to regulatory T cell treatmentSemantic proximity
Glial cell transcriptome analyses in 3xTg-AD mice: Effects of aging, disease progression, and anti-Aβ immunotherapySemantic proximity
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brainSemantic proximity
TREM2-independent neuroprotection is mediated by monocyte-derived macrophages in a mouse model of Alzheimer’s diseaseSemantic proximity
<i>Trem2</i> promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditionsSemantic proximity
Transplantation of wild-type hematopoietic stem and progenitor cells rescue Alzheimer’s disease in a mouse model and highlights the central role of microglia in disease pathogenesisSemantic proximity
Select a neighboring publication to make it the new centre.