Vaccination prevents IL-1β-mediated cognitive deficits after COVID-19

Abstract excerpt

<title>Abstract</title> <p>Up to 25% of SARS-CoV-2 patients exhibit post-acute cognitive sequelae. Although millions of cases of COVID-19-mediated memory dysfunction are accumulating worldwide, the underlying mechanisms and how vaccination lowers risk are unknown. Interleukin-1, a key component of innate immune defense against SARS-CoV-2 infection, is elevated in the hippocampi of COVID-19 patients. Here we show...

Topics

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• Amyloid beta-Protein Precursor
• Coculture Techniques
• Dependovirus
• Interleukin-10
• Long-Term Effects of COVID-19
• Maze Learning
• Neural Stem Cells
• Neurogenesis

Identifiers and source

Literature Corpus work

84b3fb19-0399-58be-8d0e-eea5509885fa

DOI

10.21203/rs.3.rs-3353171/v1