Article

Brain Resident Memory T Cells Rapidly Expand and Initiate Neuroinflammatory Responses Following CNS Injury and Viral Infection

2022-05-20

Abstract excerpt

The contribution of circulating verses tissue resident memory T cells (TRM) to clinical neuropathology is an enduring question due to a lack of mechanistic insights. The prevailing view is TRM cells are protective against pathogens in the brain. However, the extent antigen-specific TRM cells can induce neuropathology upon reactivation has not been determined. Using the described phenotype of TRMs, we found that b...

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Literature Corpus work: f7d9e27c-7a4d-542d-8003-05e0645c116c
DOI: 10.2139/ssrn.4115859

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