Article

Caveolin-1 mediates neuroinflammation and cognitive impairment in SARS-CoV-2 infection

2023-10-19

Abstract excerpt

Leukocyte infiltration of the CNS can contribute to neuroinflammation and cognitive impairment. Brain endothelial cells regulate adhesion, activation, and diapedesis of T cells across the blood-brain barrier (BBB) in inflammatory diseases. The integral membrane protein Caveolin-1 (Cav-1) critically regulates BBB permeability, but its influence on T cell CNS infiltration in respiratory viral infections is unknown....

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Literature Corpus work: ae8de906-12f6-595a-92dc-783ef7af4078
DOI: 10.1101/2023.10.18.563024

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