Prognostic value and spatial transcriptomic landscape of histopathological growth patterns in synchronous colorectal liver metastases.

doi:10.1016/j.ejso.2026.111951

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Prognostic value and spatial transcriptomic landscape of histopathological growth patterns in synchronous colorectal liver metastases.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Aug 2026

Lin Zhu, Li Xingyu, Yi Taijun, Hua Hongpeng, Jin Huilin, Liang Yongling, Wan Yunle, Li Guolin

Abstract excerpt

BACKGROUND: Histopathological growth patterns (HGPs) are critical prognostic biomarkers in colorectal liver metastases (CRLM), yet their molecular drivers remain unclear. This study aims to validate the prognostic value of HGPs in synchronous CRLM and explore their spatial transcriptomic underpinnings. METHODS: Clinicopathological data from 182 patients with surgically resected synchronous CRLM were analyzed....

Topics

Humans
Liver Neoplasms
Colorectal Neoplasms
Prognosis
Female
Spatial Transcriptomics
Male
Middle Aged
Proto-Oncogene Proteins p21(ras)
Transcriptome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Epithelial-Mesenchymal Transition

Aged

Mutation

Disease-Free Survival

Neoplasm Staging

Survival Rate

Source

Open in PubMed

Identifiers

PMID: 42296573
DOI: 10.1016/j.ejso.2026.111951

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KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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