Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2016

Jones Lindsay L, Alli Rajshekhar, Li Bofeng, Geiger Terrence L

Abstract excerpt

How a large number of cytokines differentially signal through a small number of signal transduction pathways is not well resolved. This is particularly true for IL-6 and IL-10, which act primarily through STAT3 yet induce dissimilar transcriptional programs leading alternatively to pro- and anti-inflammatory effects. Kinetic differences in signaling, sustained to IL-10 and transient to IL-6, are critical to this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunophenotyping
Share to Interleukin-10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-6

Share to STAT3 Transcription Factor

Share to T-Lymphocyte Subsets

Share to Th1 Cells

Share to Th17 Cells

Share to Th2 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 26912317
DOI: 10.4049/jimmunol.1402953
PMCID: PMC4799746

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation.PMID 26912317Read ↗

STAT3 determines IL-4 signalling outcomes in naïve T cellsSemantic proximity Read ↗

Mechanistic pathway modeling reveals how IL-10 generates pleiotropic immune responsesSemantic proximity Read ↗

IL-6 signal transduction and its physiological roles: the signal orchestration model.Semantic proximity Read ↗

Interleukin-6 and interleukin-11: same same but differentSemantic proximity Read ↗

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses.Semantic proximity Read ↗

Interleukin-6: A Masterplayer in the Cytokine NetworkSemantic proximity Read ↗

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disordersSemantic proximity Read ↗

Historical overview of the interleukin-6 family cytokine.Semantic proximity Read ↗

Human IL-6RhiTIGIT- CD4+CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile.Semantic proximity Read ↗

Interleukin-6 and Its Receptor: A Paradigm for CytokinesSemantic proximity Read ↗

Human CCR6+ Th Cells Show Both an Extended Stable Gradient of Th17 Activity and Imprinted Plasticity.Semantic proximity Read ↗

STAT3 Signaling Heterogeneity Underlies Cytokine-Expressing Fate in Th17 Cultures.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.