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Article

More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer

7 Jul 2010

Abstract excerpt

IL-11, a member of the IL-6 family of cytokines, exerts pleiotropic activities by stimulating hemopoiesis and thrombopoiesis, regulating macrophage differentiation, and conferring mucosal protection in the intestine. These effects are mediated by a multimeric complex comprising the ligand-binding IL-11Rα and the ubiquitously expressed gp130R β-subunit, which together, trigger intracellular signaling and...

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PMID: 20610798
DOI: 10.1189/jlb.0410226

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