Article
Disease-association analysis of an inflammation-related feedback loop.
Cell reports - 28 Mar 2013
Murakami Masaaki, Harada Masaya, Kamimura Daisuke, Ogura Hideki, Okuyama Yuko, Kumai Noriko, Okuyama Azusa, Singh Rajeev, Jiang Jing-Jing, Atsumi Toru, Shiraya Sayaka, Nakatsuji Yuji, Kinoshita Makoto, Kohsaka Hitoshi, Nishida Makoto, Sakoda Saburo, Miyasaka Nobuyuki, Yamauchi-Takihara Keiko, Yamaguchi-Takihara Keiko, Hirano Toshio
Abstract excerpt
The IL-6-triggered positive feedback loop for NFκB signaling (or the IL-6 amplifier/Inflammation amplifier) was originally discovered as a synergistic-activation signal that follows IL-17/IL-6 stimulation in nonimmune cells. Subsequent results from animal models have shown that the amplifier is activated by stimulation of NFκB and STAT3 and induces chemokines and inflammation via an NFκB loop. However, its role...
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