Article

Engineered IL-10 variants elicit potent immuno-modulatory activities at therapeutic low ligand doses

2020-03-11

Abstract excerpt

<h4>ABSTRACT</h4> Interleukin-10 is a dimeric cytokine with both immune-suppressive and immune-stimulatory activities. Despite its immuno-modulatory potential, IL-10-based therapies have shown only marginal benefits in the clinic. Here we have explored whether the stability of the IL-10-receptor complex contributes to IL-10 immuno-modulatory potency. For that, we have generated an IL-10 mutant with greatly enhanc...

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Literature Corpus work: 19645406-a060-5a47-8233-509681ec1c19
DOI: 10.1101/2020.03.10.985069

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