Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses.

Science signaling - 15 Sept 2020

Gorby Claire, Sotolongo Bellón Junel, Wilmes Stephan, Warda Walid, Pohler Elizabeth, Fyfe Paul K, Cozzani Adeline, Ferrand Christophe, Walter Mark R, Mitra Suman, Piehler Jacob, Moraga Ignacio

Abstract excerpt

Interleukin-10 (IL-10) is a dimeric cytokine with both immunosuppressive and immunostimulatory activities; however, IL-10-based therapies have shown only marginal clinical benefits. Here, we explored whether the stability of the IL-10 receptor complex contributes to the immunomodulatory potency of IL-10. We generated an IL-10 mutant with enhanced affinity for its IL-10Rβ receptor using yeast surface display....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes
Share to Energy Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-10

Share to Monocytes

Share to Sf9 Cells

Share to Spodoptera

Share to STAT1 Transcription Factor

Share to STAT3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 32934073
DOI: 10.1126/scisignal.abc0653
PMCID: PMC7685028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses.PMID 32934073Read ↗

Engineered IL-10 variants elicit potent immuno-modulatory activities at therapeutic low ligand dosesSemantic proximity Read ↗

Cryo‐EM structure of the IL‐10 receptor complex provides a blueprint for ligand engineeringSemantic proximity Read ↗

Mechanistic pathway modeling reveals how IL-10 generates pleiotropic immune responsesSemantic proximity Read ↗

Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.Semantic proximity Read ↗

Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1Semantic proximity Read ↗

Noncompetitive antibody neutralization of IL-10 revealed by protein engineering and x-ray crystallography.Semantic proximity Read ↗

Dual Immune Checkpoint and Cytokine Receptor Modulation by an Engineered Human CTLA-4/IL-10 Bispecific Fusion ProteinSemantic proximity Read ↗

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines.Semantic proximity Read ↗

A mechanistically novel peptide agonist of the IL-7 receptor that addresses limitations of IL-7 cytokine therapySemantic proximity Read ↗

Interleukin‐10 in viral diseases and cancer: exiting the labyrinth?Semantic proximity Read ↗

Epstein-Barr Virus IL-10 Engages IL-10R1 by a Two-step Mechanism Leading to Altered Signaling PropertiesSemantic proximity Read ↗

Insights into IL-23 biology: From structure to functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.