Article

Haplotype-based inference of the distribution of fitness effects

2019-09-16

Abstract excerpt

Recent genome sequencing studies with large sample sizes in humans have discovered a vast quantity of low-frequency variants, providing an important source of information to analyze how selection is acting on human genetic variation. In order to estimate the strength of natural selection acting on low-frequency variants, we have developed a likelihood-based method that uses the lengths of pairwise identity-by-stat...

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Literature Corpus work: f4c9b109-66b8-5f4e-9f4f-282ce972fbc3
DOI: 10.1101/770966

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