Article
A flexible method for estimating the fraction of fitness influencing mutations from large sequencing data sets.
Genome research - 1 Jun 2016
Moon Sunjin, Akey Joshua M
Abstract excerpt
A continuing challenge in the analysis of massively large sequencing data sets is quantifying and interpreting non-neutrally evolving mutations. Here, we describe a flexible and robust approach based on the site frequency spectrum to estimate the fraction of deleterious and adaptive variants from large-scale sequencing data sets. We applied our method to approximately 1 million single nucleotide variants (SNVs)...
Topics
- Codon
- Evolution, Molecular
- Genetic Fitness
- Models, Genetic
- Mutation
- Open Reading Frames
- Polymorphism, Single Nucleotide
- Protein Interaction Maps
- Selection, Genetic
- Sequence Analysis, DNA
- Statistics, Nonparametric