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Article

Approximation to the distribution of fitness effects across functional categories in human segregating polymorphisms.

PLoS genetics - 1 Nov 2014

Racimo Fernando, Schraiber Joshua G

Abstract excerpt

Quantifying the proportion of polymorphic mutations that are deleterious or neutral is of fundamental importance to our understanding of evolution, disease genetics and the maintenance of variation genome-wide. Here, we develop an approximation to the distribution of fitness effects (DFE) of segregating single-nucleotide mutations in humans. Unlike previous methods, we do not assume that synonymous mutations are...

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Identifiers

PMID: 25375159
DOI: 10.1371/journal.pgen.1004697
PMCID: PMC4222666

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Source receipt: pubmed, retrieved 7 Sept 2026.

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