Article

Comprehensive characterization of V(D)J recombination from long-read transcriptomic data with VDJcraft

2026-04-05

Abstract excerpt

V(D)J recombination generates antigen receptor diversity in developing B and T cells. Long-read transcriptome technologies (e.g., PacBio Iso-Seq, Nanopore RNA/cDNA) capture full-length transcripts and thus resolve V(D)J events more accurately than short-read platforms. However, existing short-read tools are not applicable to or optimized for long-read data. We developed VDJcraft, the first integrated pipeline desi...

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Literature Corpus work: f4c6b2db-fc36-5fc9-ac7b-f1d0399f2feb
DOI: 10.64898/2026.04.01.715879

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