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Article

Automated analysis of high-throughput B-cell sequencing data reveals a high frequency of novel immunoglobulin V gene segment alleles.

Proceedings of the National Academy of Sciences of the United States of America - 24 Feb 2015

Gadala-Maria Daniel, Yaari Gur, Uduman Mohamed, Kleinstein Steven H

Abstract excerpt

Individual variation in germline and expressed B-cell immunoglobulin (Ig) repertoires has been associated with aging, disease susceptibility, and differential response to infection and vaccination. Repertoire properties can now be studied at large-scale through next-generation sequencing of rearranged Ig genes. Accurate analysis of these repertoire-sequencing (Rep-Seq) data requires identifying the germline...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Rearrangement, B-Lymphocyte

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Source

Open in PubMed Open full text

Identifiers

PMID: 25675496
DOI: 10.1073/pnas.1417683112
PMCID: PMC4345584

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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