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Article

Fast multiclonal clusterization of V(D)J recombinations from high-throughput sequencing

1 Jan 2014

Abstract excerpt

BACKGROUND: V(D)J recombinations in lymphocytes are essential for immunological diversity. They are also useful markers of pathologies. In leukemia, they are used to quantify the minimal residual disease during patient follow-up. However, the full breadth of lymphocyte diversity is not fully understood. RESULTS: We propose new algorithms that process high-throughput sequencing (HTS) data to extract unnamed V(D)J...

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PMID: 24885090
DOI: 10.1186/1471-2164-15-409

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