Article
ImmunoTyper-SR: A computational approach for genotyping immunoglobulin heavy chain variable genes using short-read data.
Cell systems - 19 Oct 2022
Ford Michael K B, Hari Ananth, Rodriguez Oscar, Xu Junyan, Lack Justin, Oguz Cihan, Zhang Yu, Weber Sarah, Magliocco Mary, Barnett Jason, Xirasagar Sandhya, Samuel Smilee, Imberti Luisa, Bonfanti Paolo, Biondi Andrea, Dalgard Clifton L, Chanock Stephen, Rosen Lindsey, Holland Steven, Su Helen, Notarangelo Luigi, Vishkin Uzi, Watson Corey T, Sahinalp S Cenk
Abstract excerpt
Human immunoglobulin heavy chain (IGH) locus on chromosome 14 includes more than 40 functional copies of the variable gene (IGHV), which are critical for the structure of antibodies that identify and neutralize pathogenic invaders as a part of the adaptive immune system. Because of its highly repetitive sequence composition, the IGH locus has been particularly difficult to assemble or genotype when using standard...
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