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Article

AIRR-C IG Reference Sets: curated sets of immunoglobulin heavy and light chain germline genes.

Frontiers in immunology - 1 Jan 2023

Collins Andrew M, Ohlin Mats, Corcoran Martin, Heather James M, Ralph Duncan, Law Mansun, Martínez-Barnetche Jesus, Ye Jian, Richardson Eve, Gibson William S, Rodriguez Oscar L, Peres Ayelet, Yaari Gur, Watson Corey T, Lees William D

Abstract excerpt

Introduction: Analysis of an individual's immunoglobulin (IG) gene repertoire requires the use of high-quality germline gene reference sets. When sets only contain alleles supported by strong evidence, AIRR sequencing (AIRR-seq) data analysis is more accurate and studies of the evolution of IG genes, their allelic variants and the expressed immune repertoire is therefore facilitated. Methods: The Adaptive Immune...

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Identifiers

PMID: 38406579
DOI: 10.3389/fimmu.2023.1330153
PMCID: PMC10884231

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