Article

Pleiotrophin drives a pro-metastatic immune niche within the breast tumor microenvironment

2022-05-02

Abstract excerpt

Metastatic cancer cells adapt to thrive in secondary organs. To investigate metastatic adaptation, we performed transcriptomic analysis of metastatic and non-metastatic murine breast cancer cells. We found that pleiotrophin (PTN), a neurotrophic cytokine, is a metastasis-associated factor that is expressed highly by aggressive breast cancers. Moreover, elevated PTN in plasma correlated significantly with metastasi...

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Literature Corpus work: f4c276d4-5ed2-58f5-95c2-74cbbbc63017
DOI: 10.1101/2022.05.02.490334

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