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Article

Single-cell RNA-sequencing identifies anti-cancer immune phenotypes in the early lung metastatic niche during breast cancer.

Clinical & experimental metastasis - 1 Dec 2022

Orbach Sophia M, Brooks Michael D, Zhang Yining, Campit Scott E, Bushnell Grace G, Decker Joseph T, Rebernick Ryan J, Chandrasekaran Sriram, Wicha Max S, Jeruss Jacqueline S, Shea Lonnie D

Abstract excerpt

Microenvironmental changes in the early metastatic niche may be exploited to identify therapeutic targets to inhibit secondary tumor formation and improve disease outcomes. We dissected the developing lung metastatic niche in a model of metastatic, triple-negative breast cancer using single-cell RNA-sequencing. Lungs were extracted from mice at 7-, 14-, or 21 days after tumor inoculation corresponding to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36002598
DOI: 10.1007/s10585-022-10185-4
PMCID: PMC9643644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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